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into the brain with unprecedented efficiency and selectivity. Key Responsibilities Develop high-throughput screening cell-based BBB models. Utilize advanced molecular biology, proteomics and microscopy to study
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model of hematopoietic differentiation. We can now use this system alone or in combination with CRISPR perturbations of transcriptional regulators, using bulk and single cell readouts. Our experimental
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- Strong background in molecular and cell biology techniques (RT-qPCR, ELISA, Western Blot). - Experience with mammalian cell culture and in vitro skin models. - Animal handling (mice models) and
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diabetes. The successful applicant will develop cell-based model systems such as human stem cell-derived beta cells, using single cell genomic read-outs, and will explore poorly understood genome regulatory
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& Simulation Installation is open to experimental users with no experience in modelling and simulation, as well as to experimental and computational users with experience in the field. Projects from experimental
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the accumulation of beta amyloid and neuronal cell death. Yet, it is not clearly understood how the cellular crosstalk between glia and neurons is regulated at the molecular level nor how it drives neurodegeneration