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-scale screens to study fundamental principles in molecular and complex trait genetics using microbes as model systems. Our core technology MAGESTIC (https://doi.org/10.1038/nbt.4137 ), a CRISPR/Cas9-based
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). We are seeking a highly motivated researcher to join our team. We use a wide range of molecular, cellular, transcriptomic, and advanced imaging techniques, in combination with ex vivo and in vivo
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, Quantum espresso); molecular dynamics simulations (e.g. LAMMPS, DL-POLY); development of inter-atomic potentials (e.g. pro-fit, MLIP-3); Demonstrated experience in meso-scale models such as cluster dynamics
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-scale screens to study fundamental principles in molecular and complex trait genetics using microbes as model systems. Our core technology MAGESTIC (https://doi.org/10.1038/nbt.4137 ), a CRISPR/Cas9-based
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processing 2. nonequilibrium physics of molecular machines 3. understanding the role of phase-separated condensates with quantitative models 4. Modeling multicellular systems in mechanobiology 5. AI assisted
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(including Crohn’s disease and ulcerative colitis) using molecular and cell biology, multi-omics technologies, murine models, and human tissues. We currently have three major focuses: 1) Innate lymphoid cells
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on the development of anti-infective drugs and vaccines using the pig as a model platform. Main tasks will include the design, coordination, and execution of pig experiments, and assessment of drug and vaccine
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simulations, statistical mechanics, computer programming (e.g., C++, Python), polymer theory, molecular modeling (e.g., of proteins, nucleic acids, ligands), coarse-grain and polymer model development
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analyzing whole organism models (zebrafish and mouse) to dissect the pathophysiology of a recently identified rare pediatric neurometabolic disorder. The approach involves mainly deep longitudinal phenotyping