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: • Design, conduct, and analyze experiments focused on molecular, biochemical, and cellular mechanisms of retinal degeneration associated with Usher Syndrome Type 2A. • Utilize knock-in mouse models
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Biochemistry, Molecular/Cell Biology, and/or BioEngineering documented by peer-reviewed publications Skills in a broad range of methods in the fields of Biochemistry, Molecular/Cell Biology, and/or
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of Biochemistry, Molecular/Cell Biology, and/or BioEngineering Experience with fluidics devices, 3D printed devices, 3D cell culture models and bioinformatics/computational biology (e.g., R, Python) is an asset
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explored. These strategies will be evaluated on cellular and mouse disease models, in order to determine whether APP editing can reduce pathogenic effects caused by amyloid-beta. In addition to gene editing
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The Fagerholm and Harjunpää groups at the Molecular and Integrative Bioscience (MIBS) Research programme, Faculty of Bio- and Environmental Sciences, University of Helsinki are inviting applications
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Postdoctoral Research Associate in Sum-Frequency Generation Microscopy of Biomolecular Self-Assembly
state-of-the-art sum-frequency generation (SFG) microscope to study biomolecular self-assembly. This would primarily involve furthering the recent efforts to elucidate the heterogeneity in molecular
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. This includes establishing and optimizing in vitro and in vivo models, conducting biomarker and mechanistic studies, and applying molecular and cellular techniques such as qPCR, Western blotting, and
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mentoring at different levels. Previous experience in advanced tissue modeling and molecular and functional characterization is prerequisite, while experience working with bacterial cultures is a plus but not
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from correcting disease-causing mutations, the potential of introducing protective mutations will be explored. These strategies will be evaluated on cellular and mouse disease models, in order to
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the feasibility of applying a wide variety of scientific principles and theories. Maintains substantial knowledge of state-of-the-art principles and theories. Develops advanced analytical models and systems and