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Field
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available to conduct research on chronic pain. Using animal pain models, behavioral tests, calcium imaging, patch-clamp, optogenetics, neuroanatomy, molecular biology, the successful candidate is expected
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, which has seen little improvement in patient survival over the past decades. Utilizing genetically engineered mouse and human glioma models, our lab investigates how glioma cells interact with the tumor
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summary and responsibilities Define the role of primary cilia in glial cells in development and disease, using both mouse models and human cells. Analyze data from molecular, genetic, imaging, and
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spectroscopy and HPLC), organic synthesis, electrochemistry, hydrogel soft matter and modelling. You will be mentored by Dr. Maguire and will learn how to design and manage projects, how to conduct research, how
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TZ complexes, you are expected to determine the molecular structure and function of a TZ sub-complex consisting of 3-5 proteins. You will monitor the gating mechanism of TZ in cellular models such as
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molecular interactions between ICB and γδ T cells. Position 2 will focus on the potential role of γδ T cells in immune related adverse effects (irAEs). Both positions will be in close collaboration with
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, tailored, complex materials such as advanced polymers or polymeric formulations, catalysts, mechatronic devices and software and algorithms. Design, control and modelling and analyses complement
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supervising studies that involve in vitro assays and in vivo mouse tumor models to understand mechanisms of immunotherapy resistance, exploration of pathways involved in signal transduction in different T cell
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they release their toxic cargo to kill the cancer cells. Methods include, but are not limited to, in vitro culture of primary human cells and cell lines, organ-on-chip models, molecular biology, diverse
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and stem cell biology. The study investigates how APOE4 expression in endothelial cells affects oligodendrocyte progenitor cells (OPCs), using iPSC-derived 3D co-culture models. This work aims to