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and regenerative medicine. This project will focus on developing patient-derived stem cell models to advance autologous cell replacement therapy for diabetes. The PhD will involve: Generating patient
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). Access to cutting-edge facilities, including advanced microscopy, controlled environment growth rooms, genomics, proteomics, and metabolomics platforms. Opportunities to work across model and crop species
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diversity. We work to identify the genes that regulate plant development, describe the evolutionary histories of these genes, and connect the molecular evolution of developmental genes to the evolution
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microenvironment. Genetic deletion of GBPs in either GBM cells or TAMs reduces tumour growth and extends survival in preclinical models, highlighting their potential as dual-function therapeutic targets This project
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fees and international fees. Overview Are you interested in working with non-animal complex 3D models of human disease in the fields of tissue inflammation and fibrosis? Organ fibrosis is a global unmet
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the pathogenic mechanisms of amyotrophic lateral sclerosis (ALS)/frontotemporal dementia (FTD) using in vitro & in vivo (mouse and fly) models. We develop stem cell-based models for these neurodegenerative
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opportunity to translate high-resolution molecular data into practical tools for non-clinical drug safety and regulatory science. This has the potential to revolutionise our ability to detect and understand
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modelling of the gut microbiome. This is a unique opportunity to work within a dynamic, multidisciplinary team of microbiologists, clinicians, and molecular scientists with a strong track record in
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sequencing. Assess the inflammatory properties of Bio-MNPs using patient samples and established disease models, including precision-cut liver slices, and immunological assays. This fully funded PhD project
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between obesity and CSC expansion (Picon-Ruiz et al., 2017) suggest exercise will mitigate CSC-driven breast cancer progression. Most cellular/molecular oncology investigations use 2D cell culture or animal