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cellular signaling remains a key challenge in biology and is at the heart of the project. The PhD student will be in charge of the molecular modelling aspects of the multi-scale approaches undertaken by
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approach combining cryo-electron microscopy, NMR spectroscopy, and advanced molecular modeling, the research will unravel the molecular architecture and conformational dynamics of pili and their interactions
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for modelling protein structures and protein-ligand (metabolite) interactions. Using multi-scale molecular models, we aim to predict the structural features of gibberellin (GA) transporters, a key phytohormone
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involve the use of expansion microscopy in combination with other super-resolution microscopy approaches such as STED, and molecular biology approaches (CRISPR/Cas9, RNAi), in a human cell culture model
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using a multiscale numerical approach, from atomistic to large-scale thermomechanical modeling, coupled with micromechanical experiments (see figure below). The master internship and PhD thesis will
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will involve (but not be limited to) applying sophisticated mouse genetic models of cancer and conditional gene targeting, single-cell RNA-seq, spectral flow cytometry, multiplex imaging and spatial
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of the M3i unit UPR9022 at IBMC, “Models of innate immunity in insects” at the Institute of Molecular and Cellular Biology (IBMC). Our team studies the molecular basis underlying interactions between
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methodology such as Thermodynamic modelling of multi-component planetary degassing/ingassing, Molecular Dynamic simulations of silicate melts, Petrology of melting of exoplanetary mantles, and the partitioning
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-/- strain) mimicking the characteristics of AS, to evaluate the effect of DNM3OS inhibition on disease progression; (2) Cellular models to dissect the signaling pathways and molecular mechanisms underlying
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, the process of host infection remains poorly understood at the molecular level. The fd phage, which specifically infects Escherichia coli, has been used as a model for studying these viruses. This phage