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into the intricate world of cellular and molecular signatures in monogenic immune disorders, particularly those affecting inflammatory signaling pathways such as NF-kB and ubiquitination. Utilize groundbreaking
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the molecular pathways of disease and to establish the mechanism of action of our therapeutics. The successful candidate will work with our team to analyze multi-level biomarker data generated from pre-clinical
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perturbation screens with high content molecular and imaging data to understand cellular and multi cellular combinatorial programs in cells and tissues in health and disease. You will join a highly collaborative
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molecular, cellular, or cancer biology, or a related biological or biomedical science. Have solid technical and computational skills. Experience with mammalian cell lines and lentiviral vectors, -omics
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transcriptomics and screening experiments. Analysis of perturbation and spatial-omics datasets Build predictive models delivering novel scientific insights. Who You Are: Ph.D.in Biology, Bioengineering, Molecular
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Biology, Molecular Biology, Bioengineering, Systems biology, Neuroscience, Immunology or related field Expertise in high content imaging screens and/or spatial omics experimental methods Expertise in
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. The postdoctoral fellow will initiate a research project to investigate interactions between commensal bacteria and/or pathogens and the host intestinal or respiratory mucosa at the molecular level. The successful
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on developing and applying foundational AI models to investigate clinically relevant cancer vulnerabilities and their relationship with molecular context. Spanning functional genomics and large-scale clinical
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MacKinnon. Cryo-EM analysis of PIP2 regulation in mammalian GIRK channels. (2020) Elife 9:e60552. (*equal contribution) Xiao Tao, Roderick MacKinnon. Molecular structures of the human Slo1 K+channel in