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evaluation of their efficacy to mitigate the negative impacts of T2DM on osteoprogenitors. The PhD candidate will establish and validate an in vitro model, screen new therapeutics using that model, then
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for structural variants and copy number variants (SVs/CNVs), will be used to optimize data analysis and variant discovery. The project will focus on identifying previously overlooked pathogenic variants, exploring
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this project, using extensive primary cell culture, molecular analysis, scRNAseq, non-invasive imaging analysis, along with mechanistic studies using 2D/3D culture models, we will dissect the distinct cellular
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