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features allow overcoming such limitation? The PhD project will be largely experimental with some modelling aspects, and will begin with an identification of a set of research questions based on a detailed
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finds and invades the sister chromatid (or homologous chromosome) to use it as template to copy and recover the broken DNA sequence. In comparison to HR, NHEJ is “error-prone” as it frequently requires
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chemically induced protein degradation. This will allow us to model developmental diseases and unravel the physiological role of BAF subunits and specific BAF complexes in human developmental processes. With
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in TDP-43-mediated R-loop suppression and recruitment of TDP-43 to DNA damage sites, using a combination of in vitro and cellular model systems. Specifically, we aim to address the following questions
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Management (SLUSE) IPB: Natural Resources and Environmental Sciences (NRES) UPM: Environmental Biotechnology/Environmental Engineering/Environmental System and Modeling UGM: Planning and Management of Coastal