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diverse classes of inhibitory neurons are specified and integrated into brain circuits during development. Our work bridges developmental neurobiology, disease modeling, and systems neuroscience. To do
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. The selected candidate will be working closely with a team of “drug hunters” exploring some of the latest advances in structural modelling and artificial intelligence applied to drug discovery. She/he
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central goal is to understand how these effects are shaped by human-specific SRGAP2 genes, which regulate synaptic timing via SYNGAP1. To achieve this, we will use: Xenotransplantation models of human
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or altered behavioral responses in ASD models How these changes reflect underlying shifts in cortical circuit function You will work within the Bonin and Farrow Labs, which brings deep expertise in
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training data. You will unravel the cis-regulatory code controlling context-dependent gene expression and use this information to design synthetic promoters. You will train and evaluate predictive models in
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intervention trials (e.g., diet, FMT), and ex vivo gut models enabling advanced multi-omics analyses of these samples. In addition the lab also maintains a large culture collection, partially linked to genomic
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critical roles of ion channels—particularly the TRP superfamily—in physiological and pathological processes. Our interdisciplinary approach spans from foundational electrophysiology to translational models
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involved in: Managing lab operations – ordering supplies, maintaining lab equipment, and ensuring smooth day-to-day functioning of the lab. Working with mouse models – including colony management
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critical roles of ion channels—particularly the TRP superfamily—in physiological and pathological processes. Our interdisciplinary approach spans from foundational electrophysiology to translational models
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are seeking a motivated and enthusiastic colleague with strong computational skills in the analyses of complex data sets to join our teams. About the project We have generated advanced brain on chip models