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: - Engineer biosensors and therapeutic circuits in E. coli Nissle and other probiotic strains. - Contribute to the assembly and physicochemical characterization of SPS-coated biohybrids. - Perform 2D/3D tumor
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sophisticated mouse genetic models of cancer and conditional gene targeting, single-cell RNA-seq, spectral flow cytometry, multiplex imaging and spatial genomics data acquisition and analysis. Where to apply E
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models will be used to unravel niche-driven leukemia initiation mechanisms. Ectopic humanized in vivo BM-AML organoids will be used to validate the identified therapeutic targets. The post-doctoral fellow
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. To achieve our objectives, we will use cutting-edge technologies (CITE-seq, RNA-seq, Ribo-seq) and combine analysis in readily available relevant cellular models of cancer-experienced T cells, syngeneic mouse