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strategies, discovered within our group, to combat heart failure. The work will integrate studies using isolated cell systems with advanced in vivo models, with a particular focus on characterising newly
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research projects investigating novel strategies, discovered within our group, to combat heart failure. The work will integrate studies using isolated cell systems with advanced in vivo models, with a
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and experience: Essential criteria PhD in bioinformatics, computational biology, or a related discipline * Extensive experience and expertise in analysing/ training models on biological or chemical
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About us The Green Laboratory investigates tissue morphogenesis and the action of morphogens. We use animal models to investigate the physical morphogenesis of tissues. It is part of the vibrant and
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biopsies and in a newly developed swine ALS model. The postholder will lead wet-lab experimental work, across biophysical (MANT-ATP) and functional genomic assays (methylome, transcriptome and proteome
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individual muscle fibre, this project will determine the subtype-specific dysregulation of SkM in ALS, both in human patient biopsies and in a newly developed swine ALS model. The postholder will lead wet-lab
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pipeline for cochlear tissue that is suitable to translate to our various mouse models we currently have running in the lab. There will also be good opportunity to collaborate with other members of the Nolan
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administering standardised or experimental assessments. Competence in data analysis and databased management, including techniques relevant to longitudinal studies (e.g. mixed models, SEM, in R, Stata, MPlus
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various mouse models we currently have running in the lab. There will also be good opportunity to collaborate with other members of the Nolan lab working on aligned projects. The post would suit somebody
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assessments. Competence in data analysis and databased management, including techniques relevant to longitudinal studies (e.g. mixed models, SEM, in R, Stata, MPlus, or other suitable programme) Proven ability