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development, and guidance within the field tumor-immunology and cell therapy. The position focuses on in vivo reprogramming of immune cells using chimeric antigen receptor (CAR) constructs against glioblastoma
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- MERFISH) to map single-cell gene expression dynamics spatially and temporally, elucidating disease mechanisms at unprecedented resolution. Investigate the impact of mechanical forces and UV radiation
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: Targeted partial reprogramming of age-associated cell states improves markers of health in mouse models of aging. Science Translational Medicine, Sep 2024. Intervention with metabolites emulating endogenous
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the kidney’s electrolyte and water reabsorption. The postdoc will be expected to explore the potential of modulating bile acid signaling in cell and mouse models and perform metabolomic and transcriptomic
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the possibility of extension for three years. Tiwari lab employs cutting-edge single-cell and spatial omics technologies with bioinformatics and machine learning to decipher principles of gene regulation. In
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):eadn1640; EMBO Mol Medicine, 2024, Apr; 16(4):823-853; Nature Communications, 2024, in press; npj Precision Oncology, 2024, Mar 12;8(1):64; Nature Cell Biology, 2022, 24, 1265–1277; Genes & Development
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Mol Medicine, 2024, Apr; 16(4):823-853; Nature Communications, 2024, 11;15(1):1870; npj Precision Oncology, 2024, Mar 12;8(1):64; Nature Cell Biology, 2022, 24, 1265–1277; Genes & Development, 2020
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well as environmental medicine specialists. The research interests of CPPEM span from pharmacoepidemiology to clinical studies and cell-based basic pharmacology and environmental medicine. Collectively, CPPEM has a
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and energetic constrains ammonia-oxidizing and methane-oxidizing microbes exhibit under oxygen depletion (and while producing oxygen) including single cell activity assays. Applicants should have a PhD
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and cancer. The successful candidate will investigate how extracellular vesicles promote inflammation in psoriasis with a particular focus on T-cell derived extracellular vesicles. The project is funded