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mechanisms regulating metabolic fuel homeostasis, with a particular focus on the brain’s role in metabolic regulation. We integrate human genetics, single-cell multiomics, and advanced model systems
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associations involve non-coding variants that lie within gene regulatory elements — enhancers or promoters. However, a lack of precise tools for the accurate assessment of regulatory activities, especially
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innovative digital techniques to reconstruct lost books, map knowledge networks, and reveal the hidden histories of this fascinating era. A core element of this work is the application of biomolecular methods
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regulatory mechanisms that define how cell types and tissues emerge. The project is highly interdisciplinary and will include primarily experimental work (i.e., single cell method development, high throughput
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, including analysing the conditions and mechanisms that contribute to tipping points characterised by significant tempo-shifts in both decline of old technologies and adoption of new solutions. WP3 addresses