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Join Our Research Team: Exploring Intestinal Adaptation and Aging Mechanisms The Choi Lab, in the Departments of Medicine and Molecular Pharmacology at the Albert Einstein College of Medicine, would
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questions we seek to address include: Feedback between mechanics, cell fate dynamics, and geometry driving tissue patterning. How 3D topological meshworks are shaped, constrained, and canalized. How nuclear
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. Zheng's lab works on problems at the interface of statistical, computational and biomedical sciences. The lab has developed methods to decipher gene cis-regulatory mechanisms from transcriptomics
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, and functional genomic approaches to study the biogenesis mechanism of regulatory non-coding RNAs and elucidate their roles in tumor formation, specifically medulloblastoma and melanoma. Several
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, PMID: 33214692), JCI (2018, PMID: 29480818), Nature (2014, PMID: 24670641) etc. Our mechanism-driven translational studies have led to the first-in-human clinical trial of IRE1a RNase inhibitor
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candidate to work with biogeochemical processes in coastal areas, and in the transition between land and sea, investigating nitrogen- and carbon cycling and mechanisms that promote hypoxic zones at the bottom
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focused on understanding mechanisms of treatment resistance in advanced prostate cancer through integration of clinical and molecular features of patients combined with preclinical modeling. We have used
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first-author original research publication in a high-impact factor journal. Strong mentorship skills, the ability to guide junior researchers, and a collaborative mindset to interact effectively with
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similar mechanism controls the cell fate decision between mesoderm and definitive endoderm in humans, and if not, how this fate decision is controlled. To undertake this work, I am looking for a highly
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on identifying the mechanisms of leukemogenesis and characterizing novel therapeutic targets in CEBPA mutant and inv(16) acute myeloid leukemia (AML). The lab has recently developed the first conditional knock-in