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biology lab that is focused on utilizing genetic approaches to understand and exploit resistance mechanisms to DNA damage. Our research program has a particular interest in studying the interplay between
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, cellular biology and signaling, and mouse models of disease, enhancing our understanding of how the allosteric site influences physiology and disease mechanisms. We plan to utilize drug discovery to identify
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a particular focus on cytokine-based drugs, using immune competent murine models and human cell culture systems for early drug development. We also study mechanisms and determinants of immune related
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research experiences are not required. Our lab (https://medicine.yale.edu/profile/hong-bo-zhao/) mainly investigate (1) deafness mechanisms underlying Cx26 (GJB2) gap junction gene mutations induced hearing
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understanding the mechanisms of ovarian aging, gene therapy for primary ovarian insufficiency, and discovering new genes that underlie primary ovarian insufficiency/diminished ovarian reserve. These studies range
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mechanisms in RNA-guided processes, and to develop novel genome editing applications based on the mechanistic understanding. Research details can be found in our laboratory and departmental web sites
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several NIH-funded studies of LGBTQ-affirmative treatments and mechanisms, as well as community implementation research. The postdoctoral associate would join a dynamic team of faculty, research scientists