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that restore immune function could therefore have substantial therapeutic applications. Cellular metabolism is an important mechanism regulating immune function. This PhD project will use a combination of
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methods. They will be responsible for characterizing the mechanisms of novel bioactive compounds and the medicinal chemistry optimization of these molecules. The candidate will be trained in a variety of
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PhD candidate in Design and synthesis of pyrophosphate mimetics to study enzymes involved in natural
by ADP-ribosyltransferases of the PARP family, while ADP-ribosylhydrolases remove the ADP-ribose residue. Understanding the detailed mechanisms of such modification and demodification is vital
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