Role of Cellular Senescence in Progression of Atrial Fibrillation

The role of senescence in the pathogenesis of atrial fibrillation: a target process for health improvement and drug development: Guo, G., Watterson, S., Zhang, S-D., Bjourson, A., McGilligan, V., Peace, A. & Rai, T. S. Ageing research reviews. 2021

Senescence Biomarkers CKAP4 and PTX3 Stratify Severe Kidney Disease Patients. McCallion, S., McLarnon, T., Cooper, E., English, A. R., Watterson, S., Chemaly, M. E., McGeough, C., Eakin, A., Ahmed, T., Gardiner, P., Pendleton, A., Wright, G., McGuigan, D., O’Kane, M., Peace, A., Kuan, Y., Gibson, D. S., McClean, P. L., Kelly, C. & McGilligan, V. Rai TS et al, , 26 Sept 2024, (Published online) In: Cells. 13, 19, p. 1-18 18 p., 1613.

Senescence Signatures Predict Hospitalization Risk and Severity in COVID-19 Patients Lynch, S. M., McLarnon, T., Cooper, E., McDaid, D., Guo, G., McLaughlin, J., McGilligan, V. E., Watterson, S., Shukla, P., Zhang, S.-D., Bucholc, M., English, A., Freeman, L., Irwin, R. E., Peace, A., O’Kane, M., Kelly, M., Bhavsar, M., Murray, E. K. & Gibson, D. S. & Rai TS  23 Sept 2024, (Published online) In: Aging Biology. 2, 1, p. 1-14 14 p., 20240035.

Potential Plasma Proteins (LGALS9, LAMP3, PRSS8 and AGRN) as Predictors of Hospitalisation Risk in COVID-19 Patients
McLarnon, T., McDaid, D., Lynch, S. M., Cooper, E., McLaughlin, J., McGilligan, V. E., Watterson, S., Shukla, P., Zhang, S.-D., Bucholc, M., English, A., Peace, A., O’Kane, M., Kelly, M., Bhavsar, M., Murray, E. K., Gibson, D. S., Walsh, C. P., Bjourson, A. J. & Rai, T. S., 17 Sept 2024, (Published online) In: Biomolecules. 14, 9, p. 1-17 17 p., 1163.

Role of Senescence and Aging in SARS-CoV-2 Infection and COVID-19 Disease. Lynch, S.M.; Guo, G.; Gibson, D.S.; Bjourson, A.J.; Rai, T.S. Cells 2021, 10, 3367. https://doi.org/10.3390/cells10123367

Deep learning in systems medicine. Wang H, Guillot EP, Comte B, de Miranda JL, Spiwok V, Chorbev I, Castiglione F, Tieri P, Watterson S, McAllister R, Malaquias TM, Rai TS, Zheng H. Briefings in Bioinformatics 2020.

The histone chaperone HIRA promotes the induction of host innate immune defences in response to HSV-1 infection. McFarlane S, Orr A, Roberts APE, Conn KL, Iliev V, Loney C, da Silva Filipe A, Smollett K, Gu Q, Robertson N, Adams PD, Rai TS, Boutell C. PLoS Pathogens 2019.

Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity. Rai TS*, Glass M, Cole JJ, Rather MI, Marsden M, Neilson M, Humphreys I, Everett R, Adams PD*, Nucleic Acids Research 2017

Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex. Ricketts DM, Frederick B, Hoff H, Tang Y, Schultz DC, Rai TS, Grazia Vizioli M, Adams PD, Marmorstein R. Nature Communications. 2015 Jul 10;6:7711.

HIRA orchestrates non-canonical dynamic chromatin in senescence and is required for suppression of neoplasia. Rai TS, Cole JC, Nelson DM, Dikovskaya D, McBryan T, Faller W, Tuyn Jv, Morrice N, Hewitt RN, Manoharan I, Pchelintsev NA, Ivanov A, Brock C, Drotar ME, Nixon C, Clark W, Sansom OJ, King A, Blyth K, Adams PD. Genes and Development 2014 Dec 15; 28(24): 2712-25.

p53 status determines the role of autophagy in pancreatic tumour development. Rosenfeldt MT, O'Prey J, Morton JP, Nixon C, MacKay G, Mrowinska A, Au A, Rai TS, Zheng L, Ridgway R, Adams PD, Anderson KI, Gottlieb E, Sansom OJ, Ryan KM. Nature. 2013 Dec 12; 504(7479):296-300.

Senescent cells harbour features of the cancer epigenome. Cruickshanks HA, McBryan T, Nelson DM, Vanderkraats ND, Shah PP, van Tuyn J, Rai TS, Brock C, Donahue G, Dunican DS, Drotar ME, Meehan RR, Edwards JR, Berger SL, Adams PD.  Nature Cell Biology 2013 Dec; 15(12):1495-506

Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression. Patel R, Gao M, Ahmad I, Fleming J, Singh LB, Rai TS, McKie AB, Seywright M, Barnetson RJ, Edwards J, Sansom OJ, Leung HY. J Clin Invest. 2013 Mar 1;123(3):1157-75.