Research Associate (Structural Biology of Cholesterol Transport)

University of Leicester, United Kingdom

Updated: 2 days ago
Location: City of Leicester, ENGLAND

About the role

This research is funded by the Leducq Foundation to study cholesterol transport in physiology and disease. The aim of this role is to study the structure of proteins and protein complexes that are involved in the transport of cholesterol from the plasma membrane to the endoplasmic reticulum.

The Schwabe group is looking for a Research Associate with experience of using a wide range of biochemical and biophysical techniques, including the expression and purification of protein complexes from E. coli, expression and purification of large multi-protein protein complexes complexes from mammalian cells, Cryo-EM, NMR and Crystallography.

The group is part of the Leicester Institute of Structural and Chemical Biology (LISCB), one of five flagship research institutes recently established by the University of Leicester, UK. We have excellent access to state-of-the-art structural biology technologies including an in house Krios cryo-EM microscope equipped with Falcon 3EC and GATAN K3 detector as well as the Diamond and ESRF Synchrotrons.


About you

The successful candidate will have a PhD in Structural Biology. This role requires experience of (i) the expression and purification of isotope-labelled mammalian proteins in E.coli for NMR spectroscopy; (ii) the expression and purification of mammalian proteins in E.coli for crystallisation with novel ligands and (iii) the expression and purification of mammalian membrane proteins for Cryo electron microscopy.

You will have a proven track record in conducting high quality research, an ability to work both independently and as part of a team, and experience of supervising undergraduate and MSc student projects.


Additional information

Informal enquiries are welcome and should be made to Professor John Schwabe on js336@leicester.ac.uk


Applications for job share will be considered.
 


As part of the University’s ongoing commitment to professional development, this role will also be considered on a seconded basis for existing staff members. Please ensure this is discussed with your line manager prior to applying. More information regarding secondments can be found here
 
The University of Leicester has been changing the world, and changing people’s lives, for 100 years. When you join us, you’ll become part of a community of Citizens of Change , which includes not only our staff and our current students but also thousands of Leicester graduates around the world.
 
As a diverse and forward-thinking employer, we embed the principles of equity, diversity and inclusion into everything we do. That includes not just our core missions of teaching and research, but also our support for staff, students and our local community through our values of Inspiring, Impactful and Inclusive through our values of Inspiring, Impactful and Inclusive.
 
We’re committed to the wellbeing of all our staff and to the sustainability of our environment, on our campus and beyond. We offer a competitive salary package, excellent pension scheme and a generous annual leave allowance, along with opportunities to develop your career in a supportive and collaborative environment.
 

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