Research Associate (Genomics) - School of Biosciences - 105316 - Grade 6

Position Details

School of Biosciences

Location: University of Birmingham, Edgbaston, Birmingham UK

Full time starting salary is normally in the range £32,546 to £35,116 with potential progression once in post to £39,355

Grade: 6

Full Time, Fixed Term contract up to December 2026

Closing date: 23rd April 2025

Background

To assist in research (by carrying out data collection or analyses) to create knowledge through providing research support for projects and research groups.

Join a groundbreaking research project funded by the Bill and Melinda Gates Foundation aimed at revolutionizing tuberculosis (TB) diagnostics. We're developing an innovative enzymatic lysis technique that addresses critical challenges in TB detection. Our approach tackles the complex mycobacterial cell wall using novel enzyme families, enabling rapid, low-cost diagnostic techniques. This research has the potential to dramatically improve TB testing accessibility, particularly in resource-limited settings, by creating a safer, more efficient method for extracting mycobacterial DNA for sequencing-based diagnostics and drug susceptibility testing. If you're passionate about transforming global health through innovative molecular biology and diagnostic technologies, this is your opportunity to make a meaningful impact in combating one of the world's most persistent infectious diseases.

The successful candidate will play a crucial role in developing an innovative TB diagnostic approach, collaborating across a multidisciplinary team to advance our novel enzymatic lysis technology. Key responsibilities include enzyme production and characterization, systematically testing enzyme cocktails against various Mycobacterial species to optimize DNA extraction efficiency. You will design and implement multiplex PCR protocols to generate amplicons, and utilize rapid nanopore sequencing techniques to validate and refine our end-to-end diagnostic test for drug resistance. The role demands meticulous laboratory work, involving molecular biology techniques, data analysis, and collaborative problem-solving to translate our research innovations into a practical diagnostic solution. Candidates will be expected to contribute to experimental design, conduct rigorous laboratory experiments, document results comprehensively, and participate in team discussions to iteratively improve our diagnostic methodology. 

Ideal candidates will possess a strong academic background in life sciences, with a minimum of an undergraduate degree in biochemistry, microbiology, biomedical science, or a closely related field. A master's degree is preferred. We are seeking candidates with demonstrable experience in molecular biology techniques, including DNA extraction, polymerase chain reaction (PCR), and sequencing methodologies. Specific technical skills we value include proficiency in laboratory techniques, experience with multiplex PCR, nanopore sequencing, and a demonstrated ability to work collaboratively in a research environment. Strong analytical skills, attention to detail, and the ability to document and communicate scientific findings clearly are essential. Candidates should be comfortable working in a fast-paced research setting, be adaptable to evolving research challenges, and show a genuine passion for innovative diagnostic technologies and global health solutions.

We are seeking a motivated molecular biologist to develop innovative diagnostic technologies for tuberculosis. The role involves creating novel enzymatic methods to extract mycobacterial DNA, designing multiplex PCR protocols, and using nanopore sequencing to create a rapid drug resistance diagnostic test. Working collaboratively, you'll conduct cutting-edge research to address critical challenges in TB detection. The ideal candidate will have a strong background in molecular biology techniques, a passion for global health, and the ability to translate scientific innovations into practical diagnostic solutions. 

We seek a researcher who has an eye for detail and strong problem-solving skills. You'll demonstrate intellectual agility, resilience when facing experimental challenges, and enthusiasm for collaborative scientific innovation are essential.

Role Summary

• Work within specified research grants and/or projects
• Operate within area of specialism
• Contribute to publications

Main Duties

• Collect research data; this may be through a variety of research methods, such as scientific experimentation, literature reviews, and research interviews
• Analyse research data as directed
• Present research outputs, including drafting academic publications or parts thereof, for example at seminars and as posters
• Develop or adapt techniques, models and methods
• Provide guidance as required to support staff and any students who may be assisting with research
• Deal with problems that may affect the achievement of research objectives and deadlines
• Carry out administrative tasks related directly to the delivery of the research
• Promotes equality and values diversity acting as a role model and fostering an inclusive working culture

Person Specification

• Degree or equivalent in relevant subject area 
• Practical experience of applying the relevant skills and techniques
• Ability to analyse information and communicate effectively
• Ability to access and organise resources successfully
• Knowledge of the protected characteristics of the Equality Act 2010, and how to actively ensure in day to day activity in own area that those with protected characteristics are treated equally and fairly

Informal enquiries to Josh Quick, email: j.quick@bham.ac.uk  

We believe there is no such thing as a 'typical' member of University of Birmingham staff and that diversity in its many forms is a strength that underpins the exchange of ideas, innovation and debate at the heart of University life. We are committed to proactively addressing the barriers experienced by some groups in our community and are proud to hold Athena SWAN, Race Equality Charter and Disability Confident accreditations. We have an Equality Diversity and Inclusion Centre that focuses on continuously improving the University as a fair and inclusive place to work where everyone has the opportunity to succeed. We are also committed to sustainability, which is a key part of our strategy. You can find out more about our work to create a fairer university for everyone on our website .

• Job Identification 6833
• Job Category Academic Non-clinical
• Posting Date 04/16/2025, 04:02 AM
• Apply Before 04/23/2025, 06:59 PM
• Job Schedule Full time
• Locations Edgbaston, Birmingham, West Midlands, B15 2TT, GB