7 Feb 2025
Job Information
- Organisation/Company
INSERM DR Grand Ouest- Research Field
Biological sciences- Researcher Profile
Recognised Researcher (R2)- Positions
Postdoc Positions- Country
France- Application Deadline
31 Mar 2025 - 23:59 (Europe/Paris)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
38.5- Offer Starting Date
1 Jun 2025- Is the job funded through the EU Research Framework Programme?
Not funded by a EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
A new project, called ReNAissance headed by Bruno Pitard, has been selected by an international jury as a high-risk health research program that could generate strategic conceptual or technological breakthroughs in the decades to come. The aim of ReNAissance is to advance medical research to provide a breakthrough therapeutic approach to treat infectious diseases by in copore mRNA expression encoding therapeutic antibodies.
The Pitard laboratory, in the Immunology and New Concepts in Immunotherapy (INCIT) department of Inserm and CNRS at Nantes University (France) is seeking for ReNAissance an innovative and highly motivated postdoctoral researcher to (1) design optimized mRNA molecules and establish cellular assays to demonstrate in vitro proof of concept for new RNA therapeutic leads and (2) characterize in vitro RNA expression and downstream disease-relevant biology to help prioritize candidates for in vivo study in animal models.
Director : Frédéric Altare
MAIN ACTIVITIES
- Lead mRNA element engineering efforts directed at the optimization of a novel mRNA structure design for RNA therapeutics with unprecedented levels of expression and stability
- Design and execute all-based assays in human and rodent cell lines to characterize the efficacy and safety of novel RNA therapeutic leads. Develop cell based neutralizing Ab assay against various viral targets.
- Design RNA formulation using adjunct regulatory elements for directed modulation of expressed antibody secretion.
- Understand mechanism of action of lead candidates and establish endpoints relevant to down selected mRNA antibody and infectious disease biology
ASSOCIATED ACTIVITIES
- Prepare figures and authors manuscript for submission to high impact journals
- Prepare technical updates for reporting to funding agencies
- Extensive experience in in vitro cell culture, as well as cellular based assays and analysis techniques (eg flow cytometry, confocal microcopy imaging, PCR, ELISA, western blotting, sequencing…)
- Prior experience in RNA structure design, and RNA expression
Where to apply
bruno.pitard@univ-nantes.fr
Requirements
- Research Field
- Biological sciences
- Education Level
- PhD or equivalent
Skills/Qualifications
- Ability to work independently, collaborate across disciplines and lead interdisciplinary activities to deliver project milestones
- Ability to collaborate with cross-functional teams to translate research finding into therapeutic development and guide selection of new mRNA format and chemistry
Specific Requirements
- Extensive experience in in vitro cell culture, as well as cellular based assays and analysis techniques (eg flow cytometry, confocal microcopy imaging, PCR, ELISA, western blotting, sequencing…)
- Prior experience in RNA structure design, and RNA expression
- Languages
- ENGLISH
- Level
- Excellent
- Research Field
- Biological sciences
- Years of Research Experience
- 1 - 4
Additional Information
Selection process
Applicants must send a CV (including publication list), a cover letter and contact details of three professional references to: bruno.pitard@univ-nantes.fr
Contact for further information (name, telephone/mail): Bruno.pitard@univ-nantes.fr
Additional comments
Fixed-term contract of 18 months, renewable
- Website for additional job details
https://incit.fr/
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Inserm - U1302 - INCIT
- Country
- France
- City
- NANTES
- Postal Code
- 44200
- Street
- 22 boulevard Benoni Goullin
- Geofield
Contact
- City
NANTES- Website
https://grand-ouest.inserm.fr/- Street
24 Boulevard Vincent Gâche- Postal Code
44200
STATUS: EXPIRED
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