18 Feb 2025
Job Information
- Organisation/Company
CNRS- Department
Département Biologie du Développement et Cellules Souches- Research Field
Biological sciences
Computer science
Mathematics- Researcher Profile
First Stage Researcher (R1)- Country
France- Application Deadline
10 Mar 2025 - 23:59 (UTC)- Type of Contract
Temporary- Job Status
Full-time- Hours Per Week
35- Offer Starting Date
1 May 2025- Is the job funded through the EU Research Framework Programme?
Not funded by a EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
We are looking for a physicist for a two- to three-year postdoctoral contract as part of the ERC SyG PEPS project. The aim of the project is to model, using biophysical methods, the spatio-temporal dynamics of cellular interactions and state changes underlying the dynamic homeostasis of the forebrain neural stem cell population.
- main role: to develop a model of the stem cell system based on cellular interactions mediated by the Notch signaling pathway, using a “lattice” spatial representation and a simple lineage progression inferred by morphometric and functional criteria (agent-based modeling and differential equations).
- main role: to progressively complexify the cellular states in this model by integrating continuous cell trajectory data revealed by transcriptomics (partial differential equations and compartmentalized structure).
- main role: to work at the interface with biologists to confront models with the results of induced biological perturbations, and to infer, using the models, new cellular interactions or new parameters for changes in cellular state, which can then be tested experimentally.
The laboratory is located at Institut Pasteur, CNRS UMR3738 (Developmental and Stem Cell Biology). It currently has a staff of 14 (3 postdocs, 2 PhD students, 3 CNRS researchers, 5 engineers, 1 animal technician).
The laboratory studies neural stem cells using the zebrafish brain as a model. We aim to understand how cell division and differentiation choices are regulated and coordinated.
Where to apply
- Website
- https://emploi.cnrs.fr/Candidat/Offre/UMR3738-LAUBAL0-005/Candidater.aspx
Requirements
- Research Field
- Biological sciences
- Education Level
- PhD or equivalent
- Research Field
- Computer science
- Education Level
- PhD or equivalent
- Research Field
- Mathematics
- Education Level
- PhD or equivalent
- Languages
- FRENCH
- Level
- Basic
- Research Field
- Biological sciences
- Years of Research Experience
- None
- Research Field
- Computer science
- Years of Research Experience
- None
- Research Field
- Mathematics
- Years of Research Experience
- None
Additional Information
Eligibility criteria
- Ph.D. in physics applied to biology, particularly in multicellular behavior modeling
- prior experience in biophysical modeling of cellular interactions, ideally of the Notch signaling pathway and ideally in the zebrafish model, in the form of differential equations
- would be a plus: experience in parameter sensitivity analysis and information theory
- capacity to code in R, Python or Matlab
- theoretical knowledge in developmental biology and/or stem cell biology (notions of cell state, fate, lineage, signaling)
- Website for additional job details
https://emploi.cnrs.fr/Offres/CDD/UMR3738-LAUBAL0-005/Default.aspx
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Département Biologie du Développement et Cellules Souches
- Country
- France
- City
- PARIS 15
- Geofield
Contact
- City
PARIS 15- Website
https://research.pasteur.fr/en/team/genetic-molecular-and-cellular-bases-of-development/
STATUS: EXPIRED
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