M/F post-doc to study a new small RNA delivery system to control microbial infections.

CNRS, France

Updated: about 2 months ago
Location: Paris 05, LE DE FRANCE
Job Type: FullTime
Deadline: 17 Mar 2025

25 Feb 2025
Job Information
Organisation/Company

CNRS
Department

Institut de biologie de l'Ecole Normale Supérieure
Research Field

Biological sciences
Medical sciences
Pharmacological sciences
Researcher Profile

First Stage Researcher (R1)
Country

France
Application Deadline

17 Mar 2025 - 23:59 (UTC)
Type of Contract

Temporary
Job Status

Full-time
Hours Per Week

35
Offer Starting Date

1 Apr 2025
Is the job funded through the EU Research Framework Programme?

Not funded by a EU programme
Is the Job related to staff position within a Research Infrastructure?

No

Offer Description

To characterize a novel sRNA delivery system to control microbial infections.

Avian influenza is a devastating viral disease affecting birds, with a very high mortality rate in poultry farming. Importantly, certain subtypes of avian viruses, such as H5N1, can cross the species barrier and infect humans. There is therefore an urgent need to find effective solutions to control H5N1, with treatment logistics and storage that are compatible with poultry farming conditions. Here, we propose to develop an innovative therapeutical and vaccination approach to fight avian influenza. The technology involves the administration of extracellular plant or microalgal vesicles containing antiviral small interfering RNAs and relevant antigens of H5N1. The aim of the project will be to generate and characterize plant and microalgae lines producing these active compounds in extracellular vesicles and to establish the proof of concept that such treatments can limit viral infection in a pre-clinical model.

The candidate will work in an international research team investigating the molecular mechanisms of host-pathogen interactions and the genetic and epigenetic regulation of gene expression (plant, microalgal and human cell model systems). The candidate will have access to all IBENS platforms (imaging, genomics, human cell culture, etc) and will benefit from a bench and office space within the team.


Where to apply
Website
https://emploi.cnrs.fr/Candidat/Offre/UMR8197-VALHER-162/Candidater.aspx

Requirements
Research Field
Biological sciences
Education Level
PhD or equivalent

Research Field
Medical sciences
Education Level
PhD or equivalent

Research Field
Pharmacological sciences
Education Level
PhD or equivalent

Languages
FRENCH
Level
Basic

Research Field
Biological sciences
Years of Research Experience
None

Research Field
Medical sciences
Years of Research Experience
None

Research Field
Pharmacological sciences
Years of Research Experience
None

Additional Information
Eligibility criteria

Expertise in molecular biology, biochemistry and cell biology techniques related to the characterization of small RNAs and extracellular vesicles (cloning, RT-qPCR, Western blot, co-immunoprecipitation, transfection in human cells, human cell infection and bacterial growth, deep sequencing of small RNAs and RNAs etc).


Website for additional job details

https://emploi.cnrs.fr/Offres/CDD/UMR8197-VALHER-162/Default.aspx

Work Location(s)
Number of offers available
1
Company/Institute
Institut de biologie de l'Ecole Normale Supérieure
Country
France
City
PARIS 05
Geofield


Contact
City

PARIS 05
Website

http://www.ibens.ens.fr/

STATUS: EXPIRED

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