Chercheur post-doctoral "Hemisynthesis of original bioactive amphiphilic molecules based on pentoses from lignocellulosic biomass
28 Jan 2025
Job Information
- Organisation/Company
Université de Lorraine - Laboratoire d'Etudes et de Recherche sur la matériau bois- Research Field
Chemistry- Researcher Profile
Recognised Researcher (R2)
Established Researcher (R3)- Country
France- Application Deadline
26 Feb 2025 - 22:00 (UTC)- Type of Contract
Temporary- Job Status
Full-time- Offer Starting Date
1 Apr 2025- Is the job funded through the EU Research Framework Programme?
Not funded by a EU programme- Is the Job related to staff position within a Research Infrastructure?
No
Offer Description
The project aims to develop low-molecular-weight amphiphilic derivatives with antibacterial and gelling properties derived exclusively from renewable raw materials and combining sugars derived from the hydrolysis of hardwood hemicelluloses, amino acids or small peptides and fatty acids , and also polyphenol-type compounds derived from plant biomass. One of the objectives is also to combine compounds with gelling properties and additional functionalities, in particular anti-proliferative and anti-bacterial or anti-fungal properties. One of the envisaged ideas, is to associate a polyphenol or a phenolic acid-type unit as a substitute for the aromatic units in the side chains of the amino acids responsible for the gelling properties, in order to provide antioxidant and metal cation complexing properties to act synergistically and increase antibacterial properties. The first step will therefore be to mimic the gelling molecules obtained previously, using pentoses, amino acids - or small peptides - , polyphenols and fatty acids or derivatives. After characterising the self-assembling and gelling properties of different media (aqueous or oil), the physicochemical and biological properties of the gels obtained can be characterised. The aim will also be to establish chemical structure-gelling temperature relationships in order to design gels that can be programmed to respond precisely to specific temperatures so that they can be used for medical applications.
Where to apply
- Website
- https://www.abg.asso.fr/fr/candidatOffres/show/id_offre/128095
Requirements
Specific Requirements
Organic chemist with experience in hemysynthesis and green chemistry. Experience in characterizing the self-assembly properties of amphiphilic compounds will be a plus.
Additional Information
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- Université de Lorraine - Laboratoire d'Etudes et de Recherche sur la matériau bois
- Country
- France
- City
- Nancy
- Geofield
STATUS: EXPIRED
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