<!-- ko if: isJobTitleVisible --> Postdoc in Proteases Proteomics - DTU Bioengineering <!-- /ko --> <!-- ko if: isAlreadyAppliedVisible --><!-- /ko -->

Updated: 13 days ago
Deadline: 22 Apr 2025

Job Description

If you have extended experience in targeted and shotgun proteomics and proteases biology in the skin and your career dream is to be at the forefront of system biology for cell signalling, this one-year postdoc position at DTU Bioengineering will fulfil your scientific and personal development in an international, dynamic, and curiosity-driven research team. 

This position will be affiliated with the team of Associate Professor Chiara Francavilla in the Section for Medical Biotechnology at the Department of Biotechnology and Biomedicine, Technical University of Denmark. The successful candidate will work on regulatory mechanisms of cell signalling downstream of proteases and receptor tyrosine kinases in mammalian cells and 3D organotypic skin cultures and will develop targeted and shotgun quantitative Mass Spectrometry-based proteomics methods for this project. The successful candidate will work closely with experts in bioinformatics and in cellular signalling to make informed decisions on data analysis and future experiments. 

Dr Francavilla’s team is funded by the Novo Nordisk Foundation and LEO Foundation and focuses on regulatory mechanisms of cell signalling in several cellular models. The team combines omics technologies with bioinformatics, and functional validation of candidates by biochemical, cell biology, and imaging methods (see for instance, Smith, Ferguson et al., EMBO J., 2021; Watson, Ferguson et al., Nat Comm, 2022; Ogden et al., NAR Cancer, 2023; Madzharova E et al., 2024). This international, passionate, and multidisciplinary team will work in close collaboration with the Francavilla-led team at the University of Manchester, UK, and with several scientists with diverse background in Denmark and abroad. 

Responsibilities
Your main responsibilities will be:

  • Develop quantitative methods for protease detection in skin models and mammalian cell cultures in both 2D and 3D cell cultures
  • Create and troubleshoot quantitative proteomics methods (targeted and shot-gun) using mass spectrometry, and analyze data.
  • Plan and collaborate on research activities with team members and external partners.
  • Stay updated with relevant literature and methodologies.
  • Maintain and share accurate records of findings with the team.
  • Present findings to the team, supervisor, and scientific community, promoting the lab's reputation.
  • Write reports for sponsors, research grants, and submit publications to journals.
  • Teach, supervise, and mentor undergraduate, PhD, and Master students.
  • Undertake agreed administrative tasks.
  • We expect the candidate to have following qualifications:

    • Must hold a PhD in Biochemistry, Cell Biology, Molecular Biology, or similar disciplines
    • Extensive and up-to-date theoretical and practical knowledge and proven experience in the fields of proteases, signal transduction, cutaneous biology AND LC MS/MS-based quantitative proteomics
    • Experience with data analysis and visualization (e.g. R environment and Cytoscape)
    • At least one publication in relevant peer-reviewed international journals demonstrating the above-mentioned skills
    • Good communication skills and ability to work with colleagues at all levels
    • Proven ability to undertake a complex workload with multiple and competing priorities without supervision
    • High level written and spoken English
    • A willingness to contribute to the work of others by offering practical and intellectual help
    • Be enthusiastic, committed, hard-working, and self-motivated in an international environment.

    As a formal qualification, you must hold a PhD degree (or equivalent). 

    We offer
    DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility. 

    Salary and terms of employment
    The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union.

    The period of employment is 1 year starting from 1st July 2025.

    You can read more about career paths at DTU here .

    Further information 
    Further information may be obtained from Chiara Francavilla chiafra@dtu.dk

    You can read more about DTU Bioengineering at https://www.bioengineering.dtu.dk .

    If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark .

    Application procedure  
    Your complete online application must be submitted no later than 22 April 2025 (23:59 Danish time)

    Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply now", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:

    • Application (cover letter)
    • CV
    • Academic Diplomas (MSc/PhD – in English)
    • List of publications 

    Applications received after the deadline will not be considered.

    All interested candidates irrespective of age, gender, disability, race, religion or ethnic background are encouraged to apply. As DTU works with research in critical technology, which is subject to special rules for security and export control, open-source background checks may be conducted on qualified candidates for the position.

    The Department of Biotechnology and Biomedicine (DTU Bioengineering) is an international leader in the areas of biotechnology and biomedicine. Our engineering approach to all aspects of biotechnology and biomedicine positions us as a valuable player with unique competences in a growing bio-based economy and with health systems transforming towards personalized medicine. We have a clear focus on the needs in the life science industry and point towards innovation, new businesses, and scientific services for the benefit of society. The department has extensive collaborations with national and international research units and industry. DTU Bioengineering has approx. 400 employees, of which 2/3 are scientific staff. The department is located at DTU Lyngby Campus.

    Technology for people
    DTU develops technology for people. With our international elite research and study programmes, we are helping to create a better world and to solve the global challenges formulated in the UN’s 17 Sustainable Development Goals. Hans Christian Ørsted founded DTU in 1829 with a clear mission to develop and create value using science and engineering to benefit society. That mission lives on today. DTU has 13,500 students and 6,000 employees. We work in an international atmosphere and have an inclusive, evolving, and informal working environment. DTU has campuses in all parts of Denmark and in Greenland, and we collaborate with the best universities around the world.



    Job Info
    • Job Identification 5026
    • Job Category VIP B
    • Posting Date 04/08/2025, 08:15 AM
    • Apply Before 04/22/2025, 05:59 PM
    • Locations Søltofts Plads, Kgs. Lyngby, 2800, DK


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