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longstanding expertise in transgenic approaches including genome editing, in cell (ES, iPS) and animal models, as well as AAV vector technologies, which are employed for generating disease models, identifying
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, regionally anchored top university as it focuses on the grand challenges of the 21st century. It develops innovative solutions for the world's most pressing issues. In research and academic programs
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experiments Develop, optimize cellular assays and CRISPR engineering using human iPS stem cell models and differentiation systems (2D or organoids) Perform functional validation of candidate hits using
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to 80% of host cell hemoglobin during its intraerythrocytic development. This process depends on endocytosis at cytostomes – specialized invaginations of the parasite surface – followed by trafficking
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lab) to investigate the molecular mechanisms controlling gene reactivation during development. Using human induced stem cell models with fluorescent reporters and high-throughput screening approaches