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the distribution of expression levels in tens of thousands of single cells. In this project, we will utilise state of the art single cell omics to decipher the biological processes underpinning therapeutic rAAV
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. Nonetheless, we still lack a clear understanding of the relative contribution of these risk factors and how they interact in the context of daily life to contribute to clinical and functional outcomes. The aim
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at high- relative to low-risk, and (b) the interaction between changes in neuroimaging biomarkers with clinical features, as well as the prediction of clinical decline from the baseline measures. Training
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