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terms of stem and progenitor cell and lineage reprogramming. Studies are at the cellular and molecular level using novel molecular and imaging methodologies to understand processes and cell interactions
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techniques, image analysis, genetic manipulations, biophysical approaches, and collaborate with theoreticians to address these questions. The specific details and aims of the project will be driven by
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imaging techniques and/or behavioral testing in rodents is advantageous. It is an advantage to have expertise in genetic cell tracing techniques. Experience in managing mouse colonies with multiple
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of immune cells as key regulators of the tumor microenvironment. Collaboration with pathologists for tissue imaging correlations and with computational biologists is expected. The work will largely involve
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biology (cryo-EM, X-ray crystallography, NMR), chemistry, biophysics, cellular imaging, etc. and the lab also has expertise and equipment for mass spectrometry including Bruker timsTOF (HT/Ultra) and
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Quezada (UCL Cancer Institute) and Prof Mark Lythgoe (UCL Centre of Advanced Biological Imaging). This project will build on a strong track record of significant discoveries in the field of tumour
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, as well as cutting-edge technologies, including 10x Genomics, spatial transcriptomics, and fully automated imaging systems for tissues and cell cultures. This is an excellent opportunity for a
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diseases, particularly in cardiometabolic, brain, and reproductive health. The Centre integrates emerging big data types - such as multi-omics, longitudinal health records, and clinical imaging - to drive
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embryonic stem cells to different tissue types as 2D and 3D gastruloids Technical expertise in advanced live imaging Technical expertise in molecular biology Excellent track record of writing papers as
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submission Good knowledge and experience in in vivo calcium imaging or electrophysiology Experience in data analysis in Python or MATLAB Track record of writing papers as evidenced by publications