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PhD position: Repair of DNA double strand breaks by break-induced replication repair pathway (m/f/d)
are non-homologous end-joining (NHEJ) and homologous recombination (HR). Usually, HR is considered “error-free” pathway as the broken DNA duplex finds and invades the sister chromatid (or homologous
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to repair. The major pathways used by cells to repair DSBs are non-homologous end-joining (NHEJ) and homologous recombination (HR). Usually, HR is considered “error-free” pathway as the broken DNA duplex
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stands out among the ten functional homologs present in humans because of the pH dependency of its chloride/sulfate exchange and the presence of a unique glutamate residue in the anion binding site
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