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renewable award. You will lead a programme of research in the molecular mechanisms of cardiovascular disease, that may include a range of approaches including targeted genetic murine models, primary cell
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and shipping for multiomic and spatial transcriptomic analysis. Validation of targets identified will be performed using bespoke organoid biology approaches on primary tumour and genetically engineered
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genetic therapeutics. Within this centre, the Lieberam group investigates nerve muscle connectivity and disease that affect neuromuscular systems and cortical circuitry, using human iPSC-based tissue
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for someone who... Holds or is near completion of a PhD in Virology. Has substantial experience with astrovirus reverse genetics. Has substantial experience with viral polyprotein processing research
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, drug/genetic screens, and cancer research would be advantageous. Previous laboratory experience in mammalian cell culture, cell and molecular biology and fluorescence microscopy is essential. Experience
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Senior Postdoctoral Research Associate in Multiomics About the Role We are one of the world leaders in the genetic discovery of molecular traits, such as metabolites and proteins, which we use
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maintenance and resistance to chemo, radio and immuno-therapy, using genetic barcoding and clonal lineage tracing and single-cell and spatial omics. You will be a core member of the team, assisting with lab
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, this causing them to increase their disease virulence. We have isolated a number of selected parasite lines from coinfections and plan to understand the molecular and genetic basis of how they have adapted after
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to identify underlying genetic mechanisms. Whilst new technologies promise improved diagnoses and treatments, less attention has been directed towards the needs of, and support for, those affected by
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Metabolism (OCDEM) on studies related to circadian rhythms in population health. This post is part of a large, interdisciplinary research programme, offering attractive opportunities to work across