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the emergence of FLT3-inhibitor resistant clones. The aim of this PhD position is to investigate primary cells, PDX and cell line models, and use a variety of methods to specifically identify adaptive changes in
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related field Experience in molecular biology methods (e.g. PCR, NGS, cell culture) and/or functional cell assays Interest in translational leukemia research and innovative imaging and omics technologies
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biology, biomedicine, biotechnology, bioinformatics or a related field Experience in molecular biology methods (e.g. PCR, NGS, cell culture) and/or functional cell assays Strong interest in cancer biology
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. Your Profile Master degree (or similar) in molecular biology, biomedicine, biotechnology, bioinformatics or a related field Experience in molecular biology methods (e.g. PCR, NGS, cell culture) and/or
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adults, characterised by severe genomic instability and a lack of targeted therapies. Using cutting-edge methods and unique primary patient-derived cell models, this project will seek to understand
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Responsible planning and implementation of experiments within the framework of the scientific project plan Develop and establish new methods in the laboratory to enable new research approaches Isolation
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of experiments within the framework of the scientific project plan Develop and establish new methods in the laboratory to enable new research approaches Isolation of primary cardiomyocytes and analysis
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. Strong interest in advanced neurofunctional assessments and methods (e.g., computer vision, bioacoustics, machine learning/AI, neuroimaging, eye-tracking, multimodal data fusion) and/ or willingness
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of substrate- triggered disaggregase activation and how the different layers are functionally intertwined. Methods that will be used: Construction, purification and characterization of disaggregase mutants