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PhD studentship: Defining the role of the pioneer factor FOXA1 in hormone-dependent cancer Supervisor: Professor Jason Carroll Course start date: 1st October 2026 Project details For further
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chromatin profiling methods along with CRISPR/Cas9-meduated cell line engineering and various animal models. You will study the effects of the activation or depletion of chromatin-modifying enzymes using
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of cancer, namely adenocarcinoma, which was driven by a transcriptional pathway that involves Androgen Receptor (AR) and a pioneer factor called FOXA1 that helps tether AR to the chromatin. Recent new
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building blocks to elicit properties far beyond simple averaging over the component materials involved, instead giving exciting opportunities for new functionalities that are not found in natural materials
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the proteins associated with their binding sites with a view to understanding therapeutic mechanisms [e.g. see Nature Biotechnology 2023, 41 1265]. We are expanding this work to create methods to characterise
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will be tasked with the development of new models for the early detection of CIN cancers, applying bleeding edge computational methods and machine learning approaches to improve detection and
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situ, with direct structure determination, and (ii) investigating and optimizing methods for chirality determination using electron crystallography. Candidate We are looking for a highly motivated and
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? What observational facilities and methods will allow investigation of bodies beyond the Solar System, the remote sensing of their atmospheres and the search for signatures of geological and biological
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technologies, bulk and single-cell RNA-sequencing, flow cytometry, multiplex immunofluorescence, and standard molecular biology and biochemistry techniques. A computational component may also be available
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of our approach is the innovation of novel methods to investigate genome function. For example, we have recently developed ways to map the binding of nucleic acid-interacting drugs and small molecules