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of the dissertation Literature research Development of methods to optimise the proton dose distribution in the presence of magnetic fields from our in-beam magnetic resonance (MR) imaging prototypes Planning
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morphological and biochemical methods as well as transcriptomic approaches at different time points during RO maturation. We expect robust phenotypes such as altered morphology and differentially spliced genes in
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expression patterns. Our approach combines genomic, molecular, neurobiological, comparative, and computational methods to link genome architecture to neural circuit organization and to understand
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-based method, named “LinkageID”, to systematically isolate cellular factors associated with particular linkages. By applying this technique in mammalian cell culture and budding yeast, we aim to identify
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will make use of sophisticated mouse genetic systems, single cell sequencing and high dimensional flow cytometry as well as multiple cellular and molecular methods used in the lab. If you are interested
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). The in vivo part of this project will be performed in her lab. Methodology We combine a variety of immunologic, metabolic and multi-omics methods to understand the phenotypic changes and mechanistic
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the following scientific questions will be addressed by applying multiple methods and techniques from molecular biology, cell biology and biochemistry: (1.) How does the loss of the tumor suppressor trigger
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in the genome do R-loops appear upon TDP-43 loss-of-function? The project involves a wide methods spectrum, ranging from protein biochemistry and biophysics (in vitro assays with recombinant proteins
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public spheres in a differentiated manner. Adopting a comparative and transnational perspective, the RTG takes into account digital, praxeological, cultural studies and philological methods and supports