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: From Mechanisms to Therapies”. In this CRC we aim to understand how plasticity i.e. non-genetic adaptations of the bone marrow niche induced by the disease or therapeutic agents contribute to drug
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“Cellular Plasticity in Myeloid Malignancies: From Mechanisms to Therapies”. In this CRC we will focus on myeloid malignancies as a model to dissect the various molecular mechanisms that enable and regulate
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this advanced manufacturing process will open new opportunities: devices with variable mechanical and chemical properties; fully 3D-printed electronics; and devices with mechanical or electrical responses encoded
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biology, and vaccine science. The Blasi laboratory has two main areas of research: 1) understanding the mechanisms and implications of viral infections in the kidney, including HIV and SARS-CoV-2 and 2
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PhD candidate in Design and synthesis of pyrophosphate mimetics to study enzymes involved in natural
by ADP-ribosyltransferases of the PARP family, while ADP-ribosylhydrolases remove the ADP-ribose residue. Understanding the detailed mechanisms of such modification and demodification is vital
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integration and plasticity at spinal nociceptive synapses, with particular emphasis on sex-specific mechanisms and glial adaptations that may influence the transition from acute to chronic pain, as well as its
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of research results in scientific journals and conferences. Qualifications: Good understanding of solid mechanics and preferably modeling of damage and/or fracture. Experience with experimental work and data
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sequencing, bulk and single-cell RNA-seq. These methodologies will be refined and later applied to Welsh genomic resources (SAIL/AWMGS) to identify patient subgroups, uncover disease-driving mechanisms, and
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to mechanical forces. We work with leading international groups on modeling and also conduct simulations at DTU. Our overarching goal is to understand and predict the mechanical behavior of metals during plastic
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/fluid mechanics as well as polarizing optics. Experience with liquid crystals and polymeric liquids is a strong asset. An M.Sc. in physics is ideal, but also materials science, mechanics or chemistry M.Sc