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HBIGS Heidelberg Biosciences International Graduate School | Heidelberg, Baden W rttemberg | Germany | about 2 months ago
segments—is a key pathological feature contributing to fibrosis and renal decline. Lipid droplet (LD) formation occurs in the endoplasmic reticulum (ER) once sufficient triacylglcyerol (TAG) has built up in
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this project, we will move towards phase-separating droplets with more than one component as they typically occur in physiological conditions. We will use a variety of techniques, including small-angle X-ray
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the Job related to staff position within a Research Infrastructure? No Offer Description PhD Project Role of glycosphingolipids in lipid droplet formation during diabetic kidney disease (Simons420
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single filaments and single droplets to composite networks using techniques such as optical tweezers, fluorescence microscopy and atomic force microscopy. The concrete activities during the project will
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, we have a major interest in studying lipid metabolism in kidney physiology and pathophysiology. Here, we are focusing on mechanisms of lipotoxicity, lipid droplet formation and contact sites between
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physiology and pathophysiology. Here, we are focusing on mechanisms of lipotoxicity, lipid droplet formation and contact sites between the endoplasmic reticulum, lipid droplets and mitochondria in conditions
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macrophase separation, leading to visible “protein/RNA” droplets, has been widely studied and suggested to be a mechanism underlying so-called membraneless organelles, potential associative mechanisms