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, you will engineer synthetic promoters controlling context-specific gene expression in Arabidopsis. You will develop high-throughput (molecular) phenotyping methods to screen transcriptional activity
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training data. You will unravel the cis-regulatory code controlling context-dependent gene expression and use this information to design synthetic promoters. You will train and evaluate predictive models in
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neuron electrophysiology as well as complex network dynamics in the context of specific perturbations. You will use these data to map the disease in terms of electrophysiological dynamics and stratify
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the interface of the expertise of the De Wit lab (molecular mechanisms of synaptic connectivity) and the Holtmaat lab (synaptic integration of sensory input and context in cortical circuits). The project will
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flow cytometry and developing a multi-dimensional platform to phenotype microglia, you will aim to identify functional subsets of microglia in the context of neurodevelopment and neuroinflammation