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disinfectants. With antimicrobial resistance (AMR) on the rise, there is an urgent need for non-antibiotic strategies to prevent and control biofilm formation on medical devices. This PhD project proposes a novel
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Supervisors: Prof Manish Tiwari Prof Shervanthi Homer-Vanniasinkam Clinical Partner: The Royal National Orthopaedic Hospital (RNOH) Collaborator: Dr. Priya Mandal – UCL Mechanical Engineering
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the synergistic effects of monoclonal antibodies and colistin. Building on extensive preliminary data, the project aims to uncover the mechanisms behind this synergy using advanced biophysical and molecular
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to improve mechanical performance in composite structures under extreme loads. Emphasis will be placed on the design of hybrid configurations capable of promoting controlled and progressive failure modes
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microenvironment to weaken resistance mechanisms and enhance the efficacy of existing treatments. By manipulating stress responses in fungi such as Saccharomyces cerevisiae and Aspergillus nidulans, the project aims
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combining physical models, sensor data, computational methods, and damage and fracture mechanics concepts to create a virtual replica of the composite tank, enabling predictive maintenance, lifetime
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will uncover the interfacial solvation structure, validated through comparison between computed and experimental sum-frequency vibrational spectroscopies, as well as the mechanism of chemical
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mycobacterial infections. The student will characterise their mechanisms of action using cross-linking mass spectrometry and assess their effects on mycobacterial membrane integrity and cell wall metabolism
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mechanisms to guide the design and formulation of nanoparticles with superior drug delivery properties. Investigate the interaction between ultrasound, nanoparticles, and biofilms to assess antimicrobial
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architected materials or metamaterials (MTM) that can undergo targeted non-linear response. You will develop a computational framework that can reveal novel Multiphysics (thermo-mechanical) MTM solutions