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biophysical methods will be used to probe how the fusion kinases assemble into their oligomeric, active forms and interact with the HSP90 molecular chaperone system. New allosteric approaches to disrupt
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these pathogenic yeasts. This 4-year MRC MMB DTP project will provide training in a mixture of advanced biomolecular techniques spanning biophysics, molecular microbiology, high-resolution fluorescence microscopy
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combines time-resolved cryo-EM, biochemical and biophysical techniques to capture structural snapshots in the allosteric regulation of methylenetetrahydrofolate reductase (MTHFR), a folate metabolising
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-focused. Expected experience in one of the following or a closely related area, particularly in experimental work: biophysics, rheology, soft matter physics, or microrobotics. Further beneficial experience
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, and AI-driven methods), biochemical reconstitutions, biophysical investigations, and cell biology to uncover how ovarian cancer subvert repair pathways to ignore DNA repair. The lab was recently awarded
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monomeric de novo synthetic proteins; (3) use computational tools to create oligomers of these monomeric proteins; (4) find ways to express the genes encoding monomeric and oligomeric proteins in a variety of
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a rapid-paced environment combining a start-up, academia, and experimental medicine. This research is highly interdisciplinary and will merge Engineering, Microbiology and Biophysics to further our