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protein homeostasis under ER stress (i.e. accumulation of misfolded protein). 3 - Obtain structural information on these different complexes by microscopy & CryoEM. Main activities – • Synthetic chemistry
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, England P, Gielen M, et al. ‘An Original Potentiating Mechanism Revealed by the Cryo-EM Structures of the Human Α7 Nicotinic Receptor in Complex with Nanobodies’. Nature Communications 14, no. 1 (25
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measured compared with radiometric techniques. Nevertheless, the measurement of RNVL remains complex, due to the generally very low concentrations in samples and to spectral interferences during ICP-MS
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increase in the number of strains that are multi-resistant to antifungal agents is leading to a growing incidence of two other species, C. glabrata and C. auris. Being a complex and dynamic structure
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the formation of the inflammasome complex, setting off a cascade of inflammation. What’s even more intriguing is that AIM2 can also detect self-DNA , a crucial discovery with significant implications for cancer