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autoimmune diseases. The pathogenesis of IA involves complex cellular interactions (immune-stromal cells) and signalling pathways that trigger the synovium to transform into an invasive ‘tumor-like’ pannus. In
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for structural variants and copy number variants (SVs/CNVs), will be used to optimize data analysis and variant discovery. The project will focus on identifying previously overlooked pathogenic variants, exploring
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the nomadic, semi-settled and settled tribes living in cultivable, desert, and mountainous ecologies. The project proposes an ambitious longitudinal enquiry, combining an analysis of digitized and published
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