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hematopoietic cell development and hematologic cancers. Based on these basic mechanistic insights, the Laboratory is building innovative therapeutics to treat hematopoietic cancers that are currently without
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Degradation (TPD) therapeutic strategies to abrogate or rewire cancer cell signaling. We have recently established a new discovery platform to expand the landscape of TPD E3 ligases and targeting modalities
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organ 3D imaging at single cell resolution of the disease (PMID 34788609). This now allows them to map and functionally probe the neuro-metastatic interface (reviewed in 32302564). The work is a close
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