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Field
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engineering, microscopy, and chemical biology to investigate neuroimmune interactions and mechanisms underlying neurodegeneration, both through in vitro studies and in the context of neurological diseases. We
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these interactions modulate neural circuit function in health and disease. We are seeking a highly motivated individual to study mechanisms of how T cells modulate resident brain cells during neuroinflammation
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on cells of the innate immune system such as macrophages and neutrophils. In particular, we explore mechanisms of malignant transformation, cellular differentiation and the control of immune cell
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? How do neurons, glial cells, and immune cells communicate, and how can chemical biology help us address these interactions in health and disease? What molecular mechanisms drive neuroinflammation and
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and collaborative research using single-cell technologies and molecular, cellular, and circuit manipulations to examine the effects of the human and mouse somatosensory afferents in physiological and
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cancer cell plasticity in AML. Our overall goal is to pave the way for new cancer therapies. In our project we want to decipher the niche-related adaptive molecular mechanisms that underlie and promote
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biology and great enthusiasm for the bone marrow niche and therapy-resistance mechanisms. The PhD student will work in close collaboration with other CRC/SFB members and groups and will perform multiomics
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or stress-induced conditions is vital for uncovering how cells adapt to challenging environments. This project will focus on investigating the molecular mechanisms behind ribosome maturation in bacteria and
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Malignancies: From Mechanisms to Therapies”. In this CRC we will focus on myeloid malignancies as a model to dissect the various molecular mechanisms that enable and regulate cancer cell plasticity in AML. Our
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resistance and a profoundly immunosuppressive tumour microenvironment (TME). There is a critical need for novel therapeutic strategies that target both tumour-intrinsic mechanisms and immune evasion. Our