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Description The MAPK pathway plays crucial roles in cancer cell proliferation, survival, and therapy resistance. This project aims to dissect the compartment-specific regulation of ERK1/2 signaling
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prognostic transcriptional programs through an epigenetic switch. Nat Genet. 56(4):663-674. Siersbæk et al., 2020. IL6/STAT3 signaling hijacks ER enhancers to drive breast cancer metastasis. Cancer Cell 38(3
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Center at the Ohio State University. Research Focus: The Guo laboratory focuses on cancer metabolism, signal transduction, autophagy, and miRNA across multiple cancer types, including brain tumors, lung
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preparing people awaiting cancer treatments, not only surgery, through support for physical activity, nutrition and emotional well-being either alone or in combination, and from the point of diagnosis
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accumulation, signaling, and therapy response of colon cancer subtypes. For this, we will make use of sophisticated co-culture models including bacteria and bacterial culture supernatants, coupled to a variety
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: Understanding and Targeting Cell Cycle Control in Cancer BRIEF DESCRIPTION OF THE PROJECT: Cells must duplicate their DNA, grow, and repair DNA damage before committing to mitosis — a critical decision point that