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compounds that modulate cilia-associated signaling in pathological conditions where ciliary function is impaired, such as ciliopathies or cancer. Candidate profile We are looking for an ethusiastic, curious
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in breast cancer progression. The aims are to optimize protocols for generating human mammary organoids that faithfully recapitulate key aspects of mammary gland morphogenesis, including branching
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screening biological agents to identify compounds that modulate cilia-associated signaling in pathological conditions where ciliary function is impaired, such as ciliopathies or cancer. Candidate profile We
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gland development and a critical factor in breast cancer progression. The aims are to optimize protocols for generating human mammary organoids that faithfully recapitulate key aspects of mammary gland
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, lincRNA, mutations in TP53 and other cancer-related genes) and introduce them in clinical practice. Available PhD topics: Functions of cyclin-dependent kinase 11 (CDK11) in regulation of gene expression and
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collaboration with these groups, we will analyze a set of substrates and non-substrates of the human intramembrane rhomboid protease RHBDL2. This enzyme regulates EGFR signaling in keratinocytes, potentiates
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activating the druggable Jak/Stat3 signaling pathway. EMBO Rep 2022, e54729. [pubmed] [doi] Burocziova M, Grusanovic S, Vanickova K, Kosanovic S, Alberich-Jorda M: Chronic Inflammation Promotes Cancer
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the role of SRC-family kinases LCK and FYN in the T-cell antigen receptor signaling, which is crucial for proper T-cell development and immune response. It is known for decades that LCK, and to lesser extent
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decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway. EMBO Rep 2022, e54729. [pubmed] [doi] Burocziova M, Grusanovic S, Vanickova K, Kosanovic S, Alberich-Jorda M: Chronic
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Project description The project will investigate the role of SRC-family kinases LCK and FYN in the T-cell antigen receptor signaling, which is crucial for proper T-cell development and immune response. It