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forefront of protein science and biophysics—tackling the molecular origins of neurodegenerative diseases of the brain. The overall aim of the research is to achieve a deep understanding of how protein
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of two riboswitches in complex with small molecule ligands. Further, different biophysical screening modalities will be compared for the identification of fragment hits for RNA targets. The PhD student
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Two funded PhD positions at SDU Physics - Interdisciplinary research projects within experimental...
have: * a Masters degree in physics, biophysics or a related discipline, or equivalent research experience * an interest in biological physics * a desire to work in an inclusive, collaborative and
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with a background in microbiology, biophysics, engineering, or natural product chemistry, and a strong interest in bacterial interactions and/or secondary metabolites. The ideal candidate is passionate
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, target interaction, and biophysical properties. Optimization: Implementing Design of Experiment and Bayesian optimization techniques to guide sequence selection efficiently to balance exploration and
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sequences with improved properties. Validation: Using AlphaFold2 and other so-called oracles to further enrich the candidate sequences for proteins with proper folding, target interaction, and biophysical