10 biomedical-signal-processing PhD positions at International PhD Programme (IPP) Mainz
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and genome stability. We are particularly interested in the diverse signalling functions of the posttranslational modifier ubiquitin, which is best known for its role in protein degradation, but also
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increases transcriptome complexity in higher eukaryotes, with critical implications in developmental processes and stress responses. Studying AS events in model systems revealed the existence of diverse
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of the hematopoietic system. Proteases of the coagulation system have been implicated in the regulation of the fate of HSC (extravascular coagulation signaling) in homeostatic condition as well as in aging mouse models
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into chromatin in order to fit into the nucleus of a cell. The packaging further provides a regulatory layer for DNA accessibility and therefore all DNA-dependent processes, such as transcription, DNA repair
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discovered (Musheev et al., 2022). This reversible process may be crucial for regulating DNA repair, replication, and transcription, further underscoring the importance of understanding these epigenetic
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PhD position: Repair of DNA double strand breaks by break-induced replication repair pathway (m/f/d)
) factors like UV, X-rays, ionizing radiations etc., cellular processes like hydrolysis, oxidation, alkylation, impediment to replication fork etc., can also damage DNA endogenously. Cells have evolved
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and a disturbance of oligodendrocytes. In order to cross the BBB, the T cells must be reactivated. It is currently unknown which kind of APCs are involved in this process. A specific cell population we
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phosphorylation (OXPHOS) and other key metabolic processes influence T-cell fate decisions. Targeting these pathways could provide novel strategies to mitigate immune aging and enhance immune responses in older
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processed is poorly understood in vertebrates. This project will help address that lack of insight. PhD project: Biogenesis of small RNA precursors The basics of the piRNA system in zebrafish have been
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translocases have been shown to regulate R-loop levels in cells. In recent years, R-loops have been recognized as a major cell-intrinsic source of genomic instability, and dysregulation of R-loop processing is