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focuses on the development of innovative human mammary organoids as an advanced in vitro model to investigate breast morphogenesis, a fundamental process in mammary gland development and a critical factor
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signals and transcription factor networks govern self-renewal, cell specification, differentiation, and reprogramming is a key step for advances in cell-based therapy and perspectives for medicine. Using
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Koledová Project description This project focuses on the development of innovative human mammary organoids as an advanced in vitro model to investigate breast morphogenesis, a fundamental process in mammary
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Academy of Sciences (IPHYS) is one of the leading biomedical research institutions in the fields of neuroscience, metabolism and cardiovascular physiology in the Czech Republic. Using molecular, cellular
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the role of SRC-family kinases LCK and FYN in the T-cell antigen receptor signaling, which is crucial for proper T-cell development and immune response. It is known for decades that LCK, and to lesser extent
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tumorigenesis Characterization of cyclin-dependent kinase 12 (CDK12) substrates and their roles in regulation of transcription and tumorigenesis The mechanisms of signalling pathways deregulation in acute myeloid
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Project description The project will investigate the role of SRC-family kinases LCK and FYN in the T-cell antigen receptor signaling, which is crucial for proper T-cell development and immune response. It
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activating the druggable Jak/Stat3 signaling pathway. EMBO Rep 2022, e54729. [pubmed] [doi] Burocziova M, Grusanovic S, Vanickova K, Kosanovic S, Alberich-Jorda M: Chronic Inflammation Promotes Cancer
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decreases HSC fitness by activating the druggable Jak/Stat3 signaling pathway. EMBO Rep 2022, e54729. [pubmed] [doi] Burocziova M, Grusanovic S, Vanickova K, Kosanovic S, Alberich-Jorda M: Chronic
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., Quantum Espresso, VASP). Proficient written and oral communication skills in English. The ability to work independently and collaboratively. Admission Procedure: The admission process begins with