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-derived neurons that generalize over different patients. To test candidate intervention strategies that normalize these phenotypes. In addition to these core activities, you will perform bioinformatic
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. To achieve your goal, you will use different approaches, including but not limited to: RNA sequencing techniques (e.g. RNA-seq, TT-seq, PRO-seq); Proximity labeling approaches and pulldowns; Chromatin
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and outside the project. Required educational backgroud A MSc degree in technical medicine, bioengineering, biomedical science, immunology, biotechnology, (bio)analytical chemisty, bioinformatics
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novel as well as state-of-the-art methods to map and functionally characterize RNA structure ensembles under different cellular conditions. Explore the therapeutic potential of targeting RNA structure