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for their expression in plant colonizing bacteria and integrating them into the chromosomes of appropriate chassis. Control systems will be designed to restrict expression to target plants and ensure optimal expression
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the possibility of making “universal” vaccines by targeting these epitopes. We have validated this methodology for the influenza virus (https://www.nature.com/articles/s41467-018-06228-8) and the technology has
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interpret high-resolution datasets that reveal new insights into disease progression, with the ultimate aim of identifying novel biomarkers and therapeutic targets. You will hold a relevant PhD/DPhil
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Institute for Molecular and Computational Medicine (IMCM). You will test GSK assets and targets in established models of podocyte and mesangial cell pathology relevant to glomerular diseases. You will
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that reveal new insights into disease progression, with the ultimate aim of identifying novel biomarkers and therapeutic targets. This is a unique opportunity to work at the cutting edge of translational
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approaches including targeted genetic murine models, primary cell culture and analysis, multi-omics and bioinformatics. The biological focus will be on vascular biology, immune cell function and metabolism
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in preventing immune-mediated pathology in autoimmunity remains poorly understood. Using genetic and antibody-based targeting, we aim to dissect how these pathways modulate T-cell signalling
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the molecular mechanisms underlying disease progression and treatment resistance and identify novel therapeutic targets. You will take a lead on development of computational approaches to integrate multi-omics