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and manipulating complex data structures, Bayesian modeling, analyzing nested longitudinal data, and who are familiar with techniques for handling challenging data (e.g., highly non-normal distributions
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-target events and other genomic alterations potentially associated with genome editing. 3) The translation of the developed genome editing reagents to clinical application through in vivo safety and
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, architecture, mechanics, and function. The work will involve generating gene-targeted mouse models and characterizing them through histological, biochemical, and molecular analyses. Successful completion
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. - Develop and apply genome-wide screening strategies and protein-based tools to investigate disease mechanisms and therapeutic targets. - Collaborate with FGSR leadership and users to co-develop
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. We also study lymphatic drainage pathways in the dura mater, aiming to understand how they influence CSF dynamics and whether they can be therapeutically targeted. Our team currently includes one
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the applicability of aptameric scaffolds in designing synthetic immunological modulators and other cellular modulators. The Mallikaratchy laboratory is a chemical biology and molecular targeting lab that apply
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research cores that are broadly used, including flow cytometry, CRISPR-Cas9-mediated gene-targeting, and computational immunogenomics. The University of Pittsburgh is located in the Oakland and Shadyside
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deacetylases, including SIRT1 and HDAC6, and ion channels to control signaling pathways impacting metabolism, apoptosis, and autism, and we leverage these discoveries to develop targeted therapeutic strategies
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, metastasis, functional genomics, therapeutic target development, and cancer proteomics. Submit a full-length CV, a 3-page future research plan, and the names and contact for 3-5 references Required
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University of Massachusetts Medical School | Worcester, Massachusetts | United States | 3 months ago
their therapeutic potential both in vitro and in vivo that includes designing CRISPR-Cas targeting strategies, analyzes editing outcomes on a molecular level using next gen sequencing and ddPCR and conducts